With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.626-60-8, name is 3-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.Application In Synthesis of 3-Chloropyridine
General procedure: Under N2 atmosphere, NHC-Pd(II)-Im 1 (1.0 mol%), dry toluene (2.0 mL), aryl chlorides 2 (0.81 mmol), aryltrimethoxysilanes 3 (2.0 equiv) and TBAF?3H2O (2.0 equiv) were successively added into a Schlenk reaction tube. Then the tube was placed in a 120 C oil bath and stirred for 3 h. The mixture was then allowed to cool to room temperature, diluted with ethyl acetate and washed with brine, dried over anhydrous Na2SO4, concentrated in vacuo and then purified by flash chromatography to give the pure products 4.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-60-8, 3-Chloropyridine, and friends who are interested can also refer to it.
Reference:
Article; Gu, Zheng-Song; Shao, Li-Xiong; Lu, Jian-Mei; Journal of Organometallic Chemistry; vol. 700; (2012); p. 132 – 134;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem