641569-94-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid, molecular formula is C17H14N4O2, molecular weight is 306.32, as common compound, the synthetic route is as follows.
[DIETHYLCYANOPHOSPHONATE (ALDRICH,] Buchs, Switzerland; 0.33 mL, 2.0 [MMOL)] is added to a stirred mixture of [4-METHYL-3- [ [4- (3-PYRIDINYL)-2-PYRIMIDINYL] AMINO]-BENZOIC] acid (306 mg, 1.0 [MMOL),] [3- [ (1-HYDROXY-1-METHYLETHYL)]-5- (1,] 1, 1-trifluoromethyl) benzeneamine (220 mg, 1.0 [MMOL)] and triethylamine [(560, UL,] 4.0 [MMOL)] in 5 mL N,N-dimethylformamide at [10C.] After stirring for 3 hours at [60C,] the mixture is treated with saturated aqueous solution of sodium hydrogen carbonate and extracted three times with ethyl acetate. The combined extracts are dried (MgSO4), filtered and the solvent is evaporated off under reduced pressure to afford a crude product which is recrystallised from ethylacetate to give the title compound as a crystalline solid, m. p. [253-258C.]
Statistics shows that 641569-94-0 is playing an increasingly important role. we look forward to future research findings about 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/5281; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem