Reference of 652160-72-0, Adding some certain compound to certain chemical reactions, such as: 652160-72-0, name is 2-Bromo-5-fluoro-3-nitropyridine,molecular formula is C5H2BrFN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 652160-72-0.
step 1 : A suspension of 2-bromo-5-fluoro-3-nitropyridine (4.42 g, 20 mmol) and SnC (22.56 g, 100 mmol) in EtOH (40 mL) and concentrated HC1 (40 mL) was heated at 60 C for 1 h. The reaction mixture was concentrated under reduced pressure. To the residue was added EtOAc (100 mL) and sat’d aq. NaHC03 solution (200 mL), and the mixture was filtered with Celite and extracted with EtOAc (100 mL x 3). The organic layer was washed with saturated NaHC03, water and brine, dried (MgSO i), filtered, and concentrated under reduced pressure to afford3.1 g (80%) of 2-bromo-5-fluoropyridin-3-amine as a brown solid. MS (ESI): m/z = 191.1 [M+l]+.
According to the analysis of related databases, 652160-72-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem