The important role of 67443-38-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.Computed Properties of C5H2BrClN2O2

5-Bromo-2-(methyloxy)-3-nitropyridine Method A A solution of 25% wt sodium methoxide in methanol (2.1 L) was added to a suspension of 5-bromo-2-chloro-3-nitropyridine (1.70 kg) in methanol (6.6 L), stirred under nitrogen at 0-5 C. The reaction mixture was stirred at 5-10 C. for 2.75 hours and then water (8.5 L) was added. The reaction mixture was cooled to 20-25 C. The mixture was then concentrated under vacuum and the resultant suspension was filtered, washed with water (8.5 L then 2*4.25 L) and the solid dried under vacuum to give the title compound as an off-white solid (1.37 kg). 1H NMR (400 MHz, Chloroform-d) delta (ppm) 8.46 (s, 1H), 8.40 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67443-38-3, 5-Bromo-2-chloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Glaxo Group Limited; Hamblin, Julie Nicole; Jones, Paul Spencer; Keeling, Suzanne Elaine; Le, Joelle; Mitchell, Charlotte Jane; Parr, Nigel James; (136 pag.)US9326987; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem