Adding a certain compound to certain chemical reactions, such as: 72587-15-6, 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine
Compound WXOO2-1 (295.68 mg, 662.13 tmol) and compound WXOO1-2 (354.9 mg, 1.30 nmol) weredissolved in acetonitrile (3.00 mE) at room temperature,followed by the addition of potassium carbonate (183.03mg, 1.32 mmol). The reaction mixture was heated at roomtemperature and stirred for 2 hours. After the reaction, themixture was diluted with water (10 mE) and extracted withethyl acetate (5 mEx2). The organic phases were combinedand dried over anhydrous sodium sulfate, followed byfiltration. The filtrate was concentrated under reduced pressure to remove the solvent. The obtained residue wasisolated by column chromatography (eluent: petroleumether/ethyl acetate=1 0/1-2/1, volume ratio) to obtain thetarget product WXOO2-2. MS-ESI mlz: 464.0 [M+H].
The synthetic route of 72587-15-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.; LUO, Yunfu; YANG, Chundao; LEI, Maoyi; LIU, LING; HU, Guoping; LI, Jian; CHEN, Shuhui; US2019/177318; (2019); A1;,
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