Electric Literature of 7356-60-7 , The common heterocyclic compound, 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Put compound A (10g, 23.03mmole) and 3,5-dibromobenzaldehyde (6.63g, 25.12mmole) in the reaction tank. After fully removing the water, add 150 ml of ethanol and start stirring. Then, sodium methoxide (0.33 g, 6.2 mmole) was added, and the mixture was stirred at room temperature for 16 hours. Thereafter, 3-Amidinopyridinium chloride (3.96 g, 25.13 mmole) and sodium hydroxide (1.6 g, 40.3 mmole) were added, and 30 ml of toluene was added thereto. The heating device was turned on and heated until 75 C and reacted overnight. After the reaction was completed, the solid was collected by filtration, heated and stirred with 250 ml of toluene, and the solid was filtered to obtain a milky white compound G (about 4.7 g).
The synthetic route of 7356-60-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yulei Optoelectric Technology Co., Ltd.; Huang Helong; Zhao Dengzhi; Xu Bowei; Lai Zhenchang; Yin Lijia; Zhang Minzhong; (32 pag.)CN110746412; (2020); A;,
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