With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73781-91-6, name is Methyl 6-chloronicotinate, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.Quality Control of Methyl 6-chloronicotinate
Reference example 56:; 2-Amino-N-(5-methoxycarbonyl-2-pyridyl)-2-methyl-amine [0263] To a solution of methyl 6-chloronicotinate (3.42 g, 20.0 mmol) in 2-propanol(20 mL) were added diisopropylethylamine (4.18 mL, 24.0 mmol) and 1,2-diamino-2-methylpropane (3.14 mL, 30.0 mmol), and the mixture was refluxed at 80 DEG C for 48 hours. The reaction mixture was concentrated under reduced pressure, and chloroform and aqueous potassium carbonate solution were added to the residue. The aqueous layer was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (Chromatorex (registered trademark) NH, Fuji Silysia, hexane/ethyl acetate =5/1) to obtain the title compound (2.31 g, 10.3 mmol).yield: 52%<1>H NMR (CDCl3) delta (ppm): 8.71 (1H, d, J = 2.3 Hz), 7.95 (1H, dd, J = 8.9, 2.3 Hz), 6.40 (1H, d, J = 8.9 Hz), 5.53 (1H, t, J = 5.9 Hz), 3.86 (3H, s), 3.27 (2H, d, J = 5.9 Hz), 1.30 (2H, br s), 1.18 (6H, s).APCIMS (m/z): 224 (M + H)<+>
At the same time, in my other blogs, there are other synthetic methods of this type of compound,73781-91-6, Methyl 6-chloronicotinate, and friends who are interested can also refer to it.
Reference:
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1354882; (2003); A1;,
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