Reference of 845306-04-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 845306-04-9, name is 6-Chloro-N-methylpicolinamide. This compound has unique chemical properties. The synthetic route is as follows.
A stirred solution of Intermediate 2 (0.6g, 1.91 mmol) in dry 1 ,4-dioxane (10 mL), was added cesium carbonate (1.9g, 5.88 mmol) followed by 6-chloro-N-methylpicolinamide (0.25 g, 1.47 mmol, ABCR). Nitrogen was flushed into the solution for 20 min and Pd(OAc)2 (0.016 g, 0.07 mmol) and 2-2′-bis (diphenylphosphino)-1,1′-binaphthyl (0.091 g, 0.14 mmol) were added. The reaction mixture was stirred at 100 C for 12 h. The resulting reaction mixture was filtered through celite and evaporated under vacuum. Water (5 mL) was added and the mixture was extracted with EtOAc (50mL). The organic layer was dried over anhydrous Na2SO4 and evaporated. The resulting crude product was purified by column chromatography ( brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.94-8.92 (m, 2H), 8.41 (d, J = 4.0 Hz, 1 H), 8.09 (d, J = 8.8 Hz, 1 H), 8.01 (s, 1 H), 7.94-7.94 (m, 1 H), 7.63 (t, J = 8.4 Hz, 1 H), 7.25-7.23 (m, 1 H), 6.94 (d, J = 8.4 Hz, 1 H), 3.79-3.77 (m, 1 H), 3.58-3.58 (m, 4H), 2.77 (d, J = 4.80 Hz, 3H), 2.59-2.58 (m, 2H), 2.49-2.45 (m, 2H), 1.45 (d, J = 6.80 Hz, 3H). LCMS: (Method A) 377.2 (M +H), Rt. 2.14min, 95.23% (Max). HPLC: (Method A) Rt. 2.07min, 96.75% (Max).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 845306-04-9, 6-Chloro-N-methylpicolinamide.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem