The important role of 920966-03-6

Statistics shows that 920966-03-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid.

Electric Literature of 920966-03-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.920966-03-6, name is 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid, molecular formula is C8H5ClN2O2, molecular weight is 196.59, as common compound, the synthetic route is as follows.

Preparation 32To a solution of 4-chloro-lH-pyrrolo[2, 3-b]pyridine-5- carboxylic acid (840mg) inN,N-dimethylformamide (8.4mL) were added 1-hydroxybenzotriazole (808 mg) and 1- (3-dimethylaminopropyl) – 3-ethylcarbodiimide (929 mg) . The mixture was stirred at 600C for 30 minutes. The solution was cooled to ambient temperature and added EPO 28% ammonium hydroxide aqueous solution (1.2 ?iL) . The mixture was stirred at ambient temperature for 1 hour. To the solution were added water and chloroform and the mixture was extracted with chloroform.The extract was dried over MgSO4, filtrated and evaporated. The residue was purified by column chromatography on silica gel with chloroform and methanol (100:0 to 90:10) to give 4-chloro- lH-pyrrolo [2, 3-b]pyridine-5-carboxamide (90 mg) as a pale yellow powder.1H-NMR (DMSO-d6) delta : 6.55-6.57 (lH,m) , 7.63-7.66 (lH,m) , 7.90 (2H,br) ,8.2 9(lH,s) ,12.16(lH,brs) .MS (ESI) :m/z 218(M+Na)+.

Statistics shows that 920966-03-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid.

Reference:
Patent; ASTELLAS PHARMA INC.; WO2007/7919; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem