Application of 98198-48-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98198-48-2, name is 2-Amino-5-bromo-4-methylpyridine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 2-amino-5-bromo-4-methylpyridine (1 g, 5.4 mmol) and 2,5-dihydroxytetrahydrofuran (2.8 g, 27 mmol) in acetic acid (10 mL) was heated at 90 C in a sealed tube for 2 h. The reaction mixture was concentrated and the residue was purified by silica gel chromatography using 4: 1 hexanes/ethyl acetate, providing 14a (900 mg, 71 % yield) as a light yellow oil.
According to the analysis of related databases, 98198-48-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; WO2005/63756; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem