Application of 1659-31-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1659-31-0, name is Dipyridin-2-yl carbonate. A new synthetic method of this compound is introduced below.
General Procedure (1): A solution of (R)-2- Amino- 1-phenylethanol (0.675 g, 4.92 mmol) and di-2-pyridyl carbonate (1.06 g, 4.92 mmol) in anhydrous dichloromethane (50 ml) was stirred at RT overnight. The resultant reaction mixture was diluted with ethyl acetate (60 mL), washed with water (2×25 niL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo to get the product as a white solid. It was purified by chromatography on silica gel, eluting with 5-15 % ethyl acetate in hexanes, to yield 0.695 g (87 %) of the desired product as a white solid. 1H NMR (300 MHz, CDCl3): delta 7.42(m, 5H), 6.19 (bs, IH) 5.64 (t, IH), 4.0 (t, IH), 3.56 (dd, IH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1659-31-0, Dipyridin-2-yl carbonate, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/78523; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem