Adding a certain compound to certain chemical reactions, such as: 59237-53-5, Methyl 6-chloro-5-nitronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H5ClN2O4, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5ClN2O4
a Methyl 6-methylamino-5-nitro-nicotinate 1.6 g (7.4 mMol) of methyl 6-chloro-5-nitro-nicotinate (see Bernie et al. in J. Chem. Soc. 1951, 2590) were stirred in 20 ml of 40percent aqueous methylamine solution at room temperature for 30 minutes. The reaction mixture was then diluted with ice water, the yellow precipitate formed was filtered off and dried. Yield: 1.2 g (80percent of theory), Rf value: 0.66 (silica gel; ethyl acetate/ethanol/glacial acetic acid=90:5:5)
The synthetic route of 59237-53-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim Pharma KG; US6087380; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem