Electric Literature of 120739-77-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 120739-77-7, name is N-((6-Chloropyridin-3-yl)methyl)ethanamine. This compound has unique chemical properties. The synthetic route is as follows.
1200 kg of dichloromethane was introduced into a 2000 L reactor, and 171 kg (1 kmol) of N-ethyl-2-chloro-5-pyridinemethylamine was added thereto with stirring, 60 L of ion exchange resin 201×7, and the mixture was cooled to an internal temperature of -10 C, and added dropwise. A solution of 157 kg (1.1 kmol) of 1-dichloro-2-nitroethylene and 320 kg of dichloromethane was added dropwise over 3 hours to control the internal temperature below 0 C. After the dropwise addition, the reaction was kept at 0 C for 3 hours. After the reaction is completed, a solution containing the compound (II) is obtained. The solution was further cooled to an internal temperature of -10 C, and slowly introduced into a methylamine gas of 46.5 kg, (1.5 kmol), controlled internal temperature of 0 C or less, and a calculated amount of monomethylamine gas was passed for 3 hours, and the temperature was maintained at 0 C. 3 hours. After completion, filtration, washing the ion exchange resin with dichloromethane, the filtrate is concentrated to dryness, adding 280 kg of ethyl acetate, stirring and crystallization at room temperature for 1 hour, then cooling to 0 C, stirring and crystallization for 3 hours, centrifuging the feed, drying to obtain the acetamid The amine was 252.3 kg, the purity was 99% or more, and the yield was 93%
According to the analysis of related databases, 120739-77-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Jinjing Chemical Co., Ltd.; Chen Xuejun; Ma Jun; Tang Songqing; (6 pag.)CN108822025; (2018); A;,
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