Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 553-53-7, name is Nicotinohydrazide. A new synthetic method of this compound is introduced below., COA of Formula: C6H7N3O
Nicotinohydrazide (0.136 g; 0.1 mmol) with 10 mL of methanol is stirred in a round bottom flask followed by drop wise addition of methanolic solution of 3-bromo-5-chloro-2-hydroxybenzaldehyde(0.235 g; 0.1 mmol). The reaction mixture is then refluxed for 2 h and upon cooling to room temperature. A pale yellow crystalline solid precipitate is separated out from the mixture. Crystalline product is washed with ice-cold ethanol and dried in vacuum over anhydrous CaCl2. Pale yellow, Yield: 80 %,m.p.: 266 C. Anal. calc. for C14H10N2O2BrCl: C, 47.55; H,2.85; N, 7.92. Found: C, 46.95; H, 2.72; N, 7.32 %. ESI-MS:m/z = 355 (m+). 1H NMR (ppm) (DMSO-d6): 12.66 (1H, s,OH), 12.61 (1H, s, NH), 8.55 (1H, s, CH=N), 8.28-8.32 (1H,d, J = 7.8 Hz, H aromatic), 8.18-8.82 (1H, t, J = 1.2 Hz), 7.96-7.98 (2H, d, J = 7.2 Hz), 7.75 (s,2H) 7.59-7.63 (1H, q, J = 2.4Hz, J = 7 Hz). 13C NMR (ppm) 161.6 (C=O), 153.2 (C-O),152.7 (C=N), 110.8, 117.6, 120.2, 123.3, 127.6, 129.2, 133.1,135.5, 147.6, 148.6 (C aromatic)
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Reference:
Article; Prabhu; Parthiban; Chakkaravarthi; Prabakaran; Rajagopal; Asian Journal of Chemistry; vol. 28; 8; (2016); p. 1661 – 1666;,
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