Adding a certain compound to certain chemical reactions, such as: 63237-88-7, Pyrazolo[1,5-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 63237-88-7, blongs to pyridine-derivatives compound. Product Details of 63237-88-7
To a stirred solution of compound A (500 mg, 3.08 mmol, 1 eq) in CH2CI2 (15 ml) was added thionyl chloride (0.665 ml, 9.25 mmol, 3 eq) and the mixture was refluxed for 3 h. The mixture was cooled to RT, concentrated in vacuo and the residue was dissolved in CH2CI2 (20 ml). TEA (3 ml, 21.51 mmol, 7 eq) followed by Weinreb amine salt (450 mg, 4.62 mmol, and 1.5 eq) was added to it and the resulting mixture was stirred at 23 C for 16 h. The reaction mixture was diluted with ethyl acetate (150 ml), the combined organic layer was washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The crude material was purified by column chromatography to obtain compound B (400 mg, 63 %) as liquid compound. (0425) [0402] FontWeight=”Bold” FontSize=”10″ H NMR (DMSO-d6) delta 8.72-8.70 (d, / = 8 Hz, 1 H), 7.76-7.74 (d, / = 9 Hz, 1 H), (0426) 7.30-7.26 (m, 1 H), 7.02-7.00 (t, / = 7 Hz, 1 H), 3.73 (s, 3 H), 3.37 (s, 3 H); (0427) [0403] LCMS: m/z = 206.0 [M+H], RT = 2.27 minutes; (Program PI, Column v.
The synthetic route of 63237-88-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem