Reference of 462-08-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 462-08-8, name is Pyridin-3-amine. A new synthetic method of this compound is introduced below.
To an ice-cooled solution of 3-aminopyridine (6 g, 63.8 mmol) and triethylamine (9.72 ml_, 70.2 mmol) in 124 ml. of dichloromethane under argon, was carefully added pivaloyl chloride (7.92 mL, 64.4 mmol) in 16 mL of dichloromethane. After the addition was completed, the reaction mixture was stirred at 0 0C for 15 minutes and then at room temperature for 18 hours. The mixture was washed with water, 4% aqueous sodium bicarbonate, brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane/ethyl acetate (85:15) as eluent, to yield the title compound (8.5 g, 75%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,462-08-8, Pyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2008/131922; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem