Related Products of 17282-40-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17282-40-5, name is 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide. A new synthetic method of this compound is introduced below.
General procedure: A mixture of 4-hydroxy-6-methyl-2H-pyran-2-one (100 mg, 0.786 mmol), benzyl amine (84 mg, 0.786 mmol) in EtOH (5 mL), was stirred at room temperature for 5 min. Then benzaldehyde (83 mg, 0.147 mmol), pyridinium ylide (193 mg, 0.786 mmol), triethylamine (8 mg, 0.786 mmol) added sequentially to the mixture and it was refluxed at 80 C for 20 min till the completion of the reaction (monitored by TLC). After completion of reaction ethanol was distilled out and in the product crushed ice (25 g) was added. To this 0.5 MHCl (1 mL) was added and the resulting aqueous with suspended solids was extracted with dichloromethane (2 × 10 mL) and concentrated. Crude product was purified through column chromatography by eluting with hexanes and EtOAc mixtures (TLC, 45 % EtOAc in hexanes; Rf = 0.34). After recrystallization from EtOH, product obtained as light yellow colour crystalline solid;
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17282-40-5, 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide, and friends who are interested can also refer to it.
Reference:
Article; Tangeti, Venkata Swamy; Reddy, Boyi Harika; Evangeline, K. Sharon; Asian Journal of Chemistry; vol. 30; 2; (2018); p. 403 – 410;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem