The origin of a common compound about 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100397-96-4, 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100397-96-4, name is 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, molecular formula is C13H10BrNO, molecular weight is 276.13, as common compound, the synthetic route is as follows.Computed Properties of C13H10BrNO

1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (4 g, 14.5 mmol) was heated at reflux in DMF-DMA (13 ml) for 1 hour and concentrated. The residue was dissolved in MeOH, and to this, methylhydrazine in water (40%) (3 ml) was added. Then the reaction mixture was heated at 65 C. for 1 hour. When LC/MS indicated the reaction was completed. The mixture was concentrated and purified by column chromatography over silica gel using (PE:EA=10:1-1:1) to give 3 g of crude product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100397-96-4, 1-(4-Bromophenyl)-2-(pyridin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SU ZHOU JING HONG BIOTECH CO., LTD.; CAI, Zhen-Wei; ZHOU, Ding; LIN, Yougang; CHEN, Ping; US2013/158031; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem