Synthetic Route of 100848-70-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100848-70-2, name is 2-Methoxy-4-methylpyridine, molecular formula is C7H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Ammonia was condensed into a round bottomed flask. While cooling the liquid ammonia with a CO2/acetonebath, NaNH2 (1.73 g) was added quickly. Then, 2-methoxy-4-methylpyridine (5.02 g) was added slowly via a syringe inthe course of 5 min. The reaction mixture turned yellow immediately, but the starting material seemed to precipitate.The cooling bath was removed, and after 20 min, the reaction mixture had turned deep brown. The cooling bath wasput in place again, and sodium 2-chloroacetate (4.74 g) was added portionwise in the course of 5 min. After stirring for35 min, the cooling bath was removed; the reaction mixture had solidified partly. 50 min later, the reaction mixture wasstirring again, and after another 40 min, NH4Cl (3.29 g) was added carefully. The turbid, light brown reaction mixtureimmediately turned clear and yellow. The mixture was left stirring at RT overnight to allow the ammonia to evaporate.To the pasty residue, water (50 ml) was added to give a turbid, yellowish mixture. The pH of the mixture was adjustedto ?4 using 3M aqueous HCl; at first, a white precipitate formed, followed by dark grey lumps. The mixture was extractedwith DCM (2 x 50 mL), the combined extract was washed with brine (50 ml), dried over sodium sulfate, and concentratedin vacuo. The residue was taken up with 1M aqueous NaOH (50 ml), and washed with diethyl ether (50 ml). The basicaqueous layer was adjusted to pH ?4-5 using 3M HCl (aq), and extracted with DCM (2 x 25 ml). Then, the pH wasadjusted to pH ?3-4, and the aqueous layer was extracted again with DCM (2 x 25 ml). The combined organic layer wasdried over sodium sulfate, and concentrated in vacuo
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100848-70-2, 2-Methoxy-4-methylpyridine.
Reference:
Patent; Dr. August Wolff GmbH & Co. KG Arzneimittel; GERTSCH, Juerg; EP2435019; (2015); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem