Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032943-43-3, name is 4-Bromo-1H-pyrazolo[3,4-c]pyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 4-Bromo-1H-pyrazolo[3,4-c]pyridine
To a solution of 4-bromo-lH-pyrazolo[3,4-c]pyridine (680.0 mg, 3.43 mmol, 1.0 eq) and Pd(PPh3)4 (396.0 mg, 0.343 mmol, 0.1 eq) in DMF (15.0 mL) was added Zn(CN)2 (804.0 mg, 6.87 mmol, 2.0 eq) and the mixture was stirred at 130 C under microwave irradiation for 2 h. After the reaction was complete, the reaction mixture was diluted by EA (50.0 mL), quenched by H20 (100.0 mL), filtered. The solid was washed by EA (50.0 mL). The filtrate was extracted by EA (50.0 mL X3), washed by brine, dried over Na2S04, concentrated to get a residue which was purified by column chromatography (PE: EA = 2: 1) to provide lH-pyrazolo[3,4-c]pyridine-4-carbonitrile (210 mg, 42.3 %) as a white solid. LCMS (M+H+) m/z calculated 145, found 145.
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Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
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