Electric Literature of 1072-97-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.
A 1,2-dimethoxyethane solution (100 mL) of 2-amino-5-bromo-pyridine (5.19 g) and ethyl bromopyruvate (5.65 mL) was stirred for 2 hours at room temperature. The precipitated solid was filtered out, suspended in ethanol (180 mL) and refluxed for 2.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was neutralized with saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The extract was washed with saturated sodium chloride solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate-hexane to obtain ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate (5.48 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); delta 1.44 (3H, t, J=7.2Hz), 4.46 (2H, q, J=7.2Hz), 7.31 (1H, dd, J=1.8, 9.6Hz), 7.59 (1H, d, J=9.6Hz), 8.14 (1H, s), 8.29 (1H, d, J=1.8Hz)
Statistics shows that 1072-97-5 is playing an increasingly important role. we look forward to future research findings about 5-Bromopyridin-2-amine.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1849465; (2007); A1;,
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