In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108724-09-0, name is 7-Bromothiazolo[4,5-c]pyridine, the common compound, a new synthetic route is introduced below. name: 7-Bromothiazolo[4,5-c]pyridine
The mixture of 6-(2-amino-5-(4,4,5,5-tetramethyl- 1,3 ,2-dioxaborolan-2- yl)pyridin-3-yl)-3,4-dihydroisoquinolin-1 (2H)-one (2-24, 68 mg, 0.186 mmol), 7- bromothiazolo[4,5-cjpyridine (2-124, 40 mg, 0.186 mmol), K3P04 (79 mg, 0.372mmo1), Pd(PPh3)2C12(13 mg, 0.0018 mmol)in THF(2 mL), and H20 (0.1 mL)was stirred at 65C for 16 h under N2 atmosphere. Upon reaction completion, the resulting mixture was filtered and concentrated under reduced pressure. The resulting residue was purified by prep-HPLC (C18 column, CH3CN/H20, containing 0.05% NH4HCO3) to get title compound 1-56 (white solid, 7 mg, 10 %). LCMS: 374 [M + Hj HPLC: 100% (254 nm); ?H NMR (400 MHz, DMSO-d6) oe 9.58 (s, 1H), 9.31 (s, 1H), 8.73 (s, 1H), 8.43 (d, J= 2.4 Hz, 1H), 7.97 (s, 1H), 7.94 (d, J 7.8 Hz, 1H), 7.79 (d, J 2.3 Hz, 1H), 7.52 (d, J= 9.4 Hz, 2H), 6.22 (s, 2H), 3.42 (s, 2H), 2.97 (t, J 6.4 Hz, 2H).
The synthetic route of 108724-09-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE; GRAY, Nathanael S.; BUHRLAGE, Sara; ANDERSON, Kenneth; COTTINI, Francesca; TONON, Giovanni; (288 pag.)WO2016/161145; (2016); A1;,
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