Electric Literature of 1110782-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1110782-41-6, name is 6-Chloro-5-(trifluoromethyl)nicotinic acid. A new synthetic method of this compound is introduced below.
To a stirred solution of the appropriate amine (0.72 mmol), EDC (1.14 mmol) and HOBT (0.76 mmol) in DCM (5 mL) were added DIPEA (1.52 mmol) and the relevant carboxylic acid (0.76 mmol). The reaction mixture was stirred at r.t. for 18 h, then quenched with water (10 mL). The organic layer was separated, dried (magnesium sulphate), concentrated in vacuo and purified using preparative HPLC, to yield the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1110782-41-6, 6-Chloro-5-(trifluoromethyl)nicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; UCB PHARMA S.A.; ALI, Mezher, Hussein; BROWN, Julien, Alistair; DE CANDOLE, Benjamin, Charles; HUTCHINSON, Brian, Woodside; LANGHAM, Barry, John; NEUSS, Judi, Charlotte; QUINCEY, Joanna, Rachel; TREVITT, Graham, Peter; WO2010/146351; (2010); A1;,
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