Electric Literature of 112110-07-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under a nitrogen atmosphere, 0.1 g (0.25 mmol, 1.0 eq) of JD1001-002-12 was sequentially added to a 25 mL reactor.3.2 mL (10.0 V) THF, 0.32 g (0.75 mmol, 3.1 eq) NaHCO3, 0.38 g (0.75 mmol, 3.0 eq) 2-amino-5-trifluoromethylpyridine, heated to 60 C, stirred for 3 hours, TLC The reaction of the raw materials is detected (developing agent: PE/EA=1/1,UV254), the reaction was stopped, the reaction was quenched with water and extracted with ethyl acetate. Filtration and concentration of the organic phase gave a solid, which was purified by HPLC (CH3CN/H2O = 60:40) to afford 39 mg of JD1001-2111. Yield31%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112110-07-3, 5-(Trifluoromethyl)pyridin-3-amine.
Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Xiao Xuzhi; Zhang Poyong; Lu Faguan; Wang Zhipeng; Chen Mengran; Guo Kun; Zhou Rui; Zhang Yun; (28 pag.)CN109593061; (2019); A;,
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