The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 112110-07-3
To a solution of 5-trifluoromethylpyridin-3-amine (1 eq.) in THF (80 mL) at r.t. was added 1M sodium bis(trimethylsilylamide) in THF (2 eq.), stirred for 15 min, followed by di-tert-butyldicarbonate (1 eq.) in THF. The reaction was stirred at r.t overnight and concentrated. The concentrate was treated with 0.2M HCl aq. and EtOAc, and the organic layer was extracted, washed with NaHCO3(sat.) and brine, dried over Na2SO4, filtered and concentrated. The concentrate was purified using flash chromatography on silica gel (40% EtOAc:Hexane) to give a yellow solid as product tert-butyl 5-(trifluoromethyl)pyridin-3-ylcarbamate (31% yield). LCMS (m/z): 263.0 (MH+); LC Rt=3.84 min. 1H NMR(CDCl3) delta 8.56(m, 2H), 8.34(s, 1H), 6.71 (s, 1H), 1.55 (s, 9H).
With the rapid development of chemical substances, we look forward to future research findings about 112110-07-3.
Reference:
Patent; Burger, Matthew; Lan, Jiong; Lindvall, Mika; Nishiguchi, Gisele; Tetalman, Michelle; US2010/216839; (2010); A1;,
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