1122-54-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1122-54-9 as follows.
4-Bromoacetyl-pyridine, HBr salt; Dibromine (17.2g, 108 mmol) was added dropwise to a cold (0C) solution of 4-acetyl- pyridine (12 g, 99 mmol) in acetic acid containing 33% of HBr (165 mL) under vigourous stirring. The vigorously stirred mixture was warmed to 40C for 2h and then to 75C. After 2h at 75C, the mixture was cooled and diluted with ether (400 mL) to precipitate the product. which was recovered by filtration and washed with ether and acetone to give white crystals (100%). This material may be recrystallised from methanol and ether.
The chemical industry reduces the impact on the environment during synthesis 1122-54-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AB SCIENCE; WO2005/73225; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem