The origin of a common compound about 1122-62-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1122-62-9, 1-(Pyridin-2-yl)ethanone, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1122-62-9, name is 1-(Pyridin-2-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. 1122-62-9

1-Pyridin-2-yl-ethanol 2-Acetylpyridine (1.0 g, 8.26 mmol) was dissolved in anhydrous methanol (20 mL) and treated with sodium borohydride (0.62 g, 16.51 mmol) and stirred at ambient temperature 18 hours. A saturated solution of ammonium chloride was added and the mixture was extracted with ethyl acetate. The combined organics were washed with water and brine, dried over anhydrous sodium sulfate, evaporated and chromatographed using a gradient of 50 to 100% ethyl acetate in hexanes to provide 0.57 g (56.1%) of the title compound. MS m/z 124 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1122-62-9, 1-(Pyridin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc; US2009/170886; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem