Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1142197-14-5, name is 2-Bromo-5-cyclopropylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-5-cyclopropylpyridine
39.1 5-cyclopropyl-2-iodopyridine 2-bromo-5-cyclopropylpyridine (purchased from Combi-Phos) (500 mg, 2.52 mmol) is dissolved in 5 mL of dioxane. Copper (I) iodide (96.2 mg, 0.50 mmol), sodium iodide (946 mg, 6.31 mmol) and N,N’-dimethylethylenediamine (105 mg, 1.01 mmol) are added and the mixture is stirred at 130 C. for 2 hours. Ethyl acetate is added and the mixture is washed with half concentrated aqueous sodium bicarbonate solution. The organic phase is dried and concentrated under reduced pressure. Yield: 541 mg (87% of theory) Mass spectrometry (ESI+): m/z=245 [M+H]+
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Reference:
Patent; Boehringer Ingelheim International GmbH; GODBOUT, Cedrickx; TRIESELMANN, Thomas; VINTONYAK, Viktor; (84 pag.)US2018/37594; (2018); A1;,
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