Application of 1147422-00-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1147422-00-1, name is tert-Butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate. A new synthetic method of this compound is introduced below.
5-(2-amino-4-(4-chlorothiophen-2-yl)thiazol-5-yl)-octahydro-1H-pyrrolo[3,2-c]pyridin-1-carboxylate tert-butyl octahydro-1H-pyrrolo[3,2-c]pyridin-1-carboxylate (100mg, 0.4mmol), and 5-bromo-4-(4-chloro-thiophen-2-yl)-thiazole-2-amine (157mg, 0.5mmol) were added to N,N-dimethylformamide (4mL), and then triethylamine (447mg, 4.4mmol) was added. The mixture was warmed to 90C and reacted for 6 h. The reaction mixture was poured into water, and extracted with ethyl acetate. The organic phases were combined and washed successively with water and a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated to produce a crude product. The crude product was purified with a silica gel column chromatography to produce the title compound as a yellow solid (170mg). ESI-MS (m/z): 441.2 [M + H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1147422-00-1, tert-Butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.; CAI, Jiaqiang; YU, Nan; ZENG, Hong; SONG, Hongmei; QING, Yan; SONG, Shuai; DENG, Hanwen; TANG, Zujian; DUAN, Xiaofan; HUANG, Haitao; YE, Hong; LIU, Gang; WANG, Lichun; WANG, Jingyi; (81 pag.)EP3511332; (2019); A1;,
Pyridine – Wikipedia,
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