Adding a certain compound to certain chemical reactions, such as: 1173897-86-3, 5-Bromo-6-methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1173897-86-3, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-6-methylpicolinonitrile
5-Bromo-6-methylpicolinonitrile (0.080 g, 0.406 mmol), 9-( 1,1 -dimethyl- l-stannaethyl)-6,l l,4a-trihydromorpholino[4,3- e]pyrazino[2,3-b]pyrazin-5-one (0.150 g, 0.406 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.041 g, 0.045 mmol), tri-o-tolylphosphine (0.027 g, 0.089 mmol) and triethylamine (0.170 mL, 1.219 mmol) were placed in a sealed tube and N,N-dimethylformamide (2 mL) was added. Nitrogen gas was bubbled through the reaction mixture for five minutes and the reaction sealed and heated at 100 0C for 1 h. The resulting cloudy black mixture was diluted with methanol, filtered and the filter cake washed thoroughly with methanol. The filtrate was concentrated under reduced pressure and purified using Biotage flash chromatography (50-100 % ethyl acetate in hexanes) to give the desired product (0.117 g, 0.363 mmol, 89 % yield). MS (ESI) m/z 323.5 [M+l]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1173897-86-3, its application will become more common.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; ELSNER, Jan; HARRIS, Roy, L.; LEE, Branden; MORTENSEN, Deborah; PACKARD, Garrick; PAPA, Patrick; PERRIN-NINKOVIC, Sophie; RIGGS, Jennifer; SANKAR, Sabita; SAPIENZA, John; SHEVLIN, Graziella; TEHRANI, Lida; XU, Weiming; ZHAO, Jingjing; PARNES, Jason; MADAKAMUTIL Loui; FULTZ Kimberly; NARLA, Rama K.; WO2010/62571; (2010); A1;,
Pyridine – Wikipedia,
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