Application of 1173897-86-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1173897-86-3, name is 5-Bromo-6-methylpicolinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.032, as common compound, the synthetic route is as follows.
An argon degassed solution of 5-bromo-6-methylpyridine-2-carbonitrile 13 (3.3 mmol, 650 mg), 4,4,5,5,-tetramethyl-2-vinyl-1,3,2-dioxaborolane (3.3 mmol, 0.56 mL), tetrakis(triphenylphosphine)palladium (5 mol %, 0.16 mmol, 190 mg) and 2N aqueous sodium carbonate solution (3.4 eq., 11.22 mmol, 5.60 mL) in toluene/ethanol (2:1, 45 mL) was heated at 95 C with stirring for 16 h. The slurry was cooled to RT, diluted with ethyl acetate and water. Organic layer was then separated. The organic layer was washed with brine and dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to afford the desired product which was purified by flash chromatography over silica gel using an elution of 20% ethyl acetate in hexane to give 246 mg (Yield: 52%) of the title compound 14 as an oil. 1H NMR (400 MHz, CDCl3): delta 7.81 (1H, d, J = 8.0 Hz), 7.52 (1H, d, J = 8.0 Hz), 6.89 (1H, dd, J = 17.6 & 10.8 Hz), 5.79 (1H, d, J = 17.2 Hz), 5.58 (1H, d, J = 10.8 Hz), 2.62 (3H, s); ESI-MS: m/z 145 [M + H]+
Statistics shows that 1173897-86-3 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-methylpicolinonitrile.
Reference:
Article; Nino, Patricia; Caba, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernandez, Joan-Carles; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 9; (2016); p. 1117 – 1130;,
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