Synthetic Route of 1186194-46-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1186194-46-6, name is 5-Bromo-6-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Step 2: 1 -{[5-Bromo-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl esterThe compound of step 1 (1 .85 g, 7.97 mmol) was dissolved in thionyl chloride (6 ml) and stirred for 30 min at 60 C. The volatiles were evaporated in vacuo, the residue was dissolved in DCM and added to a stirred mixture of 1 -amino- cycloheptanecarboxylic acid methyl ester hydrochloride, EA and saturated sodium hydrogencarbonate solution with ice cooling. The mixture was stirred at room temperature overnight, the phases were separated and the aqueous phase was extracted with EA. The combined organic phases were dried over sodium sulfate and evaporated to dryness to yield the title compound (2.80 g).1H-NMR: delta = 8.62 (d, 1 H); 8.52 (s, 1 H); 8.48 (d, 1 H); 3.99 (s, 3H); 3.57 (s, 3H); 2.15- 2.01 (m, 4H); 1 .65-1 .43 (m, 8H)
According to the analysis of related databases, 1186194-46-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS; PERNERSTORFER, Josef; KLEEMANN, Heinz-Werner; SCHAEFER, Matthias; SAFAROVA, Alena; PATEK, Marcel; WO2011/53948; (2011); A1;,
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