Application of 120739-77-7 ,Some common heterocyclic compound, 120739-77-7, molecular formula is C8H11ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(2) 20.16 g of the above crude product were dissolved in 114 ml of chloroform and to the resulting solution was added a solution of 26.34 g (0.2486 mol) of sodium carbonate in 114 ml of water at 2-7 C. with stirring. Then, 13.5 g (0.0791 mol) of N-(6-chloro-3-pyridyl)methyl-N-ethylamine were dropwise added to the mixture at 5-6 C. and stirred for 40 minutes. Further, 31.59 g (0.407 mol) of 40% methylamine were dropwise added to the mixture at 3-7 C., followed by stirring for 30 minutes under ice-cooling and 30 minutes at room temperature. The separated aqueous layer was extracted with 48 ml of chloroform. The combined chloroform layers were concentrated, and the residue to which 39 ml of ethyl acetate were added was ice-cooled to precipitate pale yellowish crystals of 1-[N-(6-chloro-3-pyridyl)methyl-N-ethyl]amino-1-methylamino-2-nitroethylene. Yield: 18.15 g (84.9%). mp. 83-84 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US5364989; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem