Related Products of 1211517-76-8 ,Some common heterocyclic compound, 1211517-76-8, molecular formula is C6H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 3 A mixture of the intermediate from step 2 (150 mg, 0.54 mmol) and K2CO3 (150 mg, 1.09 mmol,) in toluene (5 mL) was degassed with Ar for 30 min. 3-bromo-5-fluoro-4-methyl-pyridine (97 muL, 0.815 mmol), CuI (5 mg, 0.027 mmol) and N,N’-dimethylethylenediamine (10 muL, 0.092 mmol) were added to the RM and heated at 100 C. in a sealed tube for 16 h. The RM was concentrated under reduced pressure, diluted with water and extracted with EtOAc. The organic layer was dried and concentrated under reduced pressure to give the crude product which was purified by CC (SiO2; 1% MeOH in CH2Cl2) to yield the title compound (115 mg, 55%). LC-MS (Method 2): m/z [M+H]+=386.2 (MW calc. 385.39); Rt=0.66 min. 1H-NMR (DMSO-d6, 400 MHz), delta (ppm)=9.94 (s, 1H), 8.48 (s, 1H), 8.36 (s, 1H), 7.98 (s, 1H), 6.60 (s, 1H), 3.91 (s, 3H), 3.85 (s, 3H), 3.69 (s, 3H), 2.19 (d, 3H, J=0.88 Hz), 2.06 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GRUeNENTHAL GMBH; VOSS, FELIX; NORDHOFF, SONJA; WACHTEN, SEBASTIAN; WELBERS, ANDRE; RITTER, STEFANIE; US2015/166505; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem