Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126325-46-0, name is 2-Amino-3-bromo-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. 126325-46-0
Preparation 1; N-(3-Bromo-6-methvl-pvridin-2-vn-acetamide; Acetic anhydride (21 mL, 223mmol) was added to a solution of 2-amino-3-bromo-6-picoline (10g, 53.46mmol) in dioxan (50ml_) and the mixture was stirred at 50C for 18 hours. The solvent was then evaporated under reduced pressure and the residue was diluted with saturated sodium hydrogen carbonate solution (150ml_). The precipitate was filtered off, washed with water and re-dissolved in dichloromethane, and the filtrate was neutralised to pH7 with saturated sodium hydrogen carbonate solution and extracted with dichloromethane (3x100ml_). The organic solutions were combined, washed with water, dried over magnesium sulfate and concentrated in vacua to give a white solid. Purification of the solid by column chromatography on silica gel, eluting with ethyl acetateiheptane, 75:25, afforded the title compound as a white solid in 75% yield, 9.2g.
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Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2006/11050; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem