Electric Literature of 13534-97-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13534-97-9, name is 6-Bromopyridin-3-amine, molecular formula is C5H5BrN2, molecular weight is 173.0106, as common compound, the synthetic route is as follows.
Example 1; 6-Bromo-3-pyridnoI.; 3-Amino-6-bromopyridinc (1.73 g, 10 mmol) was dissolved in HBF4 (5 mL, 50 % aq.) and water (5 mL) was added. To the resulting brownish solution, cooled to O0C in an ice-bath, NaNO2 (759 mg, 11 mmol) in water (5 mL) was added dropwisc. The resulting yellowish heterogenous reaction mixture was stirred for 1 h at this temperature. After addition of water (5 mL), the mixture was stirred in an oil -bath for 5 h at 1000C (gas evolution). The cooled reaction mixture was then neutralized by addition OfNaHCO3 (5 % aq.) and the product extracted with ethyl acetate (5 x 35 mL). After drying (NaiSO4) and evaporation in vacuo, the resulting brownish solid was purified by column chromatography (SiO2) using pentane/ethyl acetate (9:1) to give 1.04 g (60 %) of the title compound, mp 137-1380C (lit. 135.5-136.5 0C; den Hertog et al Rec. Tray. Chim. Pays-Bas 1959, 69, 1281).
The chemical industry reduces the impact on the environment during synthesis 13534-97-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; KAROLINSKA INSTITUTET INNOVATIONS AB; WO2009/144253; (2009); A1;,
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