The origin of a common compound about 13534-99-1

Statistics shows that 13534-99-1 is playing an increasingly important role. we look forward to future research findings about 2-Amino-3-bromopyridine.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13534-99-1, name is 2-Amino-3-bromopyridine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.13534-99-1

equipped with a mechanical stirring three 500mL flask, 30g2- amino-3-bromo-pyridine, 52.8 g as an associated boronic acid pinacol ester, 300mL1,4- dioxane, 4.2gPd (dppf)2Cl2, 59.3g of anhydrous potassium acetate, purged with nitrogen three times, heated to about 80 open overnight.TLC the reaction was complete, cooling, filtration, the filter cake washed twice with 30mL dichloromethane and the filtrate was concentrated to dryness, 200mL of methanol and 20g active carbon was stirred at room temperature overnight, filtration.Concentrated to dryness to give an oil, and petroleum ether was added 15mL 200mL MTBE heating overnight, filtered to give 28g2-amino-4-boronic acid pinacol ester in a yield of 72.8%.

Statistics shows that 13534-99-1 is playing an increasingly important role. we look forward to future research findings about 2-Amino-3-bromopyridine.

Reference:
Patent; Shanghai Rainbow Chemistry Co.,Ltd; Wu, Gang; Yan, taotao; Wei, xianli; (13 pag.)CN102786543; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem