Electric Literature of 144584-32-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 144584-32-7 as follows.
Example 31 2-Chloro-3-bromo-4-(cis-4-tert-butylcyclohexylamino)pyridine 2.2 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 1.86 g (12 mmol) of cis-4-tert-butylcyclohexylamine and 0.1 g ammonium chloride are warmed at 120 C. for 8 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated aqueous sodium hydrogencarbonate solution is added and the reaction product extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.28 g (37%); RF: 0.41 (diisopropyl ether); 1 H-NMR (CDCl3) delta 7.92 (d, 1H), 6.38 (d, 1H), 5.27 (d, 1H), 3.74 (m, 1H), 1.0-2.0 (m, 9H), 0.89 (s, 9H) ppm
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144584-32-7, its application will become more common.
Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5877322; (1999); A;,
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