Related Products of 15862-36-9 ,Some common heterocyclic compound, 15862-36-9, molecular formula is C5H2Br2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
B. 2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridineObtained (0.257 g, 87% of yield) following the procedure described in Intermediate 2 (step A) starting with 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine (0.97 mmol, 0.300 g) and phenylboronic acid (1.07 mmol, 0.130 g).ESI/MS (m/e, %): 307 [(M+1)+, 100].C. 2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridineObtained (0.258 g, yield 87%) following the procedure described in Intermediate 27, starting with 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine (0.97 mmol, 0.300 g), phenylboronic acid (1.07 mmol, 0.130 g). delta 1H NMR (300 MHz, CDCI3): 3.64 (s, 3H), 6.89-6.99 (m, 3H), 7.21-7.24 (m, 3H), 7.32- 7.37 (m, 4H), 8.50 (s, 1 H), 9.47 (s, 1 H). ESI/MS (m/e, %): 307 [(M+1)+, 100].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-36-9, its application will become more common.
Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/21696; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem