16063-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16063-70-0, name is 2,3,5-Trichloropyridine. A new synthetic method of this compound is introduced below.
Step 1 : In a sealed tube, 2,3,5-trichloro pyridine (8.0 g, 44mmol), 4-chloro aniline (6.17 g, 49 mmol), triphenyl phosphine (1.16 g, 44 mmol) and sodium-te/t-butoxide (5.09 g, 53mmol) were mixed in c-xylene (80 mL). The resulting mixture was purged with argon, added Pd(OAc)2 (0.49 g, 2.2mmol) and heated at 110 C for 12 h. After completion of the reaction, the reaction mixture was filtered through celite bed and concentrated under vacuum. The residue obtained was diluted with ethyl acetate (200 mL), washed with water, brine solution and dried over anhydrous Na2S04. The organic phase was concentrated and purified by the column chromatography (60-120 size mesh) to get the yellow solid 3,5-dichloro-//-(4-chlorophenyl)pyridin-2-amine (7.0 g, 58.23%). LCMS: (Method B) 275 (M+H), RT. 3.69 min, 1H NMR (400 MHz, DMSO-d6) : delta 8.68 (s, 1H), 8.14 (d, J = 2.28 Hz, 1H), 8.04 (d, J = 2.32 Hz, 1H), 7.68-7.66 (m, 2H), 7.34-7.32 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16063-70-0, 2,3,5-Trichloropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK PATENT GMBH; SPANGENBERG, Thomas; (129 pag.)WO2016/827; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem