Electric Literature of 1658-42-0, Adding some certain compound to certain chemical reactions, such as: 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1658-42-0.
To a stirred solution of methyl 2-(pyridin-2-yl)acetate (190 g, 1.260 mol) in 1,4- dioxane (1.9 L) was added Triton-B (Benzyl Trimethyl ammonium hydroxide) (46 mL, 0.252 mol) at room temperature and stirred for 10 min. Acrylonitrile (49.7 mL, 0.760 mol) was dissolved in 1,4-dioxane (0.9 L) and was added drop wise over period of 30 minutes. The resulting reaction mixture was stirred for 16 hr at room temperature. The reaction progress was monitored by TLC. After completion of the reaction (TLC), the reaction mixture was concentrated under reduced pressure to afford the crude title compound. Purification by column chromatography was by using (100-200 silica gels) using 15 percent ethyl acetate and pet. ether as the eluent afforded pure compound.
According to the analysis of related databases, 1658-42-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem