The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1721-26-2, name is Ethyl 2-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H11NO2
EXAMPLE 181 3-{[5-(2-Adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carbonyl]-amino}-benzoic Acid 5-(2-Adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carboxylic acid was prepared according to the procedure of Example 70, steps a and b, with the modification that 2-methyl-pyridine-3-carboxaldehyde (prepared from ethyl 2-methylnicotinate in two steps) was used in step a instead of 2-dimethylamino-benzaldehyde. It was reacted with 3-amino-benzoic acid benzyl ester according to the procedure of Example 20, step d to afford 3-{[5-(2-adamantan-1-yl-ethyl)-2-(2-methyl-pyridine-3-yl)-1H-imidazole-4-carbonyl]-amino}-benzoic acid benzyl ester. The benzyl group was removed following the procedure of Example 1, step e, to afford the title compound as a white solid. 1H NMR (300 MHz, d6-DMSO) 12.70 (1H, br s), 9.77 (1H, s), 8.49 (2H, m), 7.97 (2H, m), 7.62 (1H, d), 7.41 (1H, t), 7.35 (1H, dd), 2.87 (2H, m), 2.76 (3H, s), 1.95 (3H, br s), 1.69 (6H, m), 1.54 (6H, m), 1.44 (2H, m).
With the rapid development of chemical substances, we look forward to future research findings about 1721-26-2.
Reference:
Patent; James Black Foundation Limited; US6479531; (2002); B1;,
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