Application of 17228-64-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17228-64-7, name is 2-Chloro-6-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.
To a stirred solution of 9(7.00 g, 48.8 mmol) in CH3CN (25 mL) was added NBS (13.0 g, 73.1 mmol) at room temperature. The resulting mixture was refluxed for 24 h. Then the reaction was quenched with saturated aqueous Na2S2O3and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, n-hexane-EtOAc=98 : 2) to afford methoxypyridine 31(6.83 g, 63%) as a colorless solid.31: mp 64-65C; IR (film, cm-1): 1584, 1551, 1466, 1408, 1344, 1306, 1256, 1155, 1121, 1022, 1009; 1H-NMR (CDCl3, 500 MHz) delta: 7.72 (d, J=8.50 Hz, 1H), 6.58 (d, J=8.50 Hz, 1H), 3.92 (s, 3H); 13C-NMR (CDCl3, 125 MHz) delta: 162.4, 147.3, 143.8, 110.9, 110.1, 54.3; HR-MS (ESI-TOF): Calcd for C6H6BrClNO [(M+H)+] 221.9316. Found 221.9314.
Statistics shows that 17228-64-7 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-6-methoxypyridine.
Reference:
Article; Inai, Makoto; Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Hamashima, Yoshitaka; Kan, Toshiyuki; Chemical and Pharmaceutical Bulletin; vol. 64; 7; (2016); p. 723 – 732;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem