The origin of a common compound about 184416-83-9

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 184416-83-9, name is 2,3-Dichloropyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A solution of 2,3-dichloropyridin-4-amine (900 mg, 5.521 mmol), (Boc)2O (3012.52 mg, 13.803 mmol), Et3N (2230.61 mg, 22.085 mmol), DMAP (67.36 mg. 0.552 mmol) in CH2Cl2 was stirred at rt for 12 h. The mixture was diluted with water (100 mL) and extracted with CHI-2Cl2 (100 mL*3). The organic layers were dried (MgSO4), filtered, and the filtrate concentrated under reduced pressure. The residue was purified by column chromatography over silica gel (eluent: petrol ether/EtOAc=100:0 to 70:30). The desired fractions were collected and the solvent was concentrated under reduced pressure to afford 4,4-tert-butyl carbamate-2,3-dichloropyridin-4-amine, cpd 119a (1600 mg, 77.7% yield) as a white solid. LCMS (ESI) m/z M+1: 362.8.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 184416-83-9, 2,3-Dichloropyridin-4-amine.

Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
Pyridine – Wikipedia,
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