Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 192447-58-8, name is 2,6-Dibromo-N,N-dimethylpyridin-4-amine. A new synthetic method of this compound is introduced below., COA of Formula: C7H8Br2N2
(3) Production of 2-bromo-4-dimethylamino-6-{3-(trifluoromethyl)phenoxy} pyridine as an intermediate product 1.4 g (0.0071*1.2 mol) of 3-(trifluoromethyl) phenol was dissolved in about 20 ml of dimethyl formamide. The solution was further mixed with 0.30 g (ca. 60% in mineral oil; 0.0071*1.06 mol) of sodium hydride and then with 2.00 g (0.0071 mol) of 2,6-dibromo-4-dimethylamino pyridine. After treating the solution under reflux for about 6 hours, the solution was allowed to stand for cooling to room temperature. After the reaction solution was distributed with hexane-saturated sodium bicarbonate water, the organic phase of the obtained solution was washed with saturated brine and dried with anhydrous sodium sulfate, followed by concentration thereof. Thereafter, the concentrated solution was purified by silica gel column chromatography (eluding solution: ethyl acetate/hexane) and the obtained product was subjected to recrystallization using hexane, thereby obtaining an aimed product. Yield by weight: 1.67 g; yield by percentage: 65%; solid; melting point: 61 to 66 C.; 1 H-NMR (60 MHz, CDCl3, delta): 2.86 (6H, s), 6.88 (1H, d, J=2 Hz), 6.38 (1H, d, J=2 Hz), 6.9-7.5 (4H, complex).
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Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US6005112; (1999); A;,
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