Application of 19437-26-4 ,Some common heterocyclic compound, 19437-26-4, molecular formula is C11H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a 300 mL three-necked flask was added 30 mL of a dehydrated THF solution of 4.12 g of Compound I and the mixture was stirred at -78 C.To this was dropped 6.3 mL of 1.58 M n-BuLi hexane solution, and the mixture was stirred for 2.5 hours. To this was added 45 mL of a dehydrated THF solution of 1.64 g of di-2-pyridinyl-methanone, and the mixture was stirred for 2 hours and then stirred at room temperature for 3 hours. After the reaction, 1N hydrochloric acid aqueous solution was added to this mixture and stirred for 1 hour. After washing with water and concentrating the obtained organic phase, a viscous solid was obtained. This viscous solid, 30 mL of glacial acetic acid and 1.4 mL of hydrochloric acid were placed in a 300 mL flask, and the mixture was heated and stirred at 130 C. for 2 hours under a nitrogen atmosphere to react. After the reaction, the reaction mixture was added dropwise to ice-cooled 150 mL of water. After precipitating white crystals, the produced solid was filtered off, washed with methanol and then dried. Finally, 4.15g (83% yield) of a white powder of Compound 111 was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19437-26-4, its application will become more common.
Reference:
Patent; SAMSUNG DISPLAY COMPANY LIMITED; ITOI, HIROAKI; MIYAKE, HIDEO; KAWAMURA, HISAYUKI; (119 pag.)JP2017/203026; (2017); A;,
Pyridine – Wikipedia,
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