19524-06-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19524-06-2, name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[Referential Example 237] 4-(Pyridin-4-yl)benzoic acid hydrochloride: 4-Bromopyridine hydrochloride (11.7 g) and 4-carboxyphenylboric acid (10.0 g) were dissolved in a mixed solvent of toluene (250 ml) and water (250 ml), tetrakis(triphenylphosphine)palladium(0) (5.0 g) and anhydrous sodium carbonate (25.4 g) were successively added, and the mixture was heated under reflux at 120¡ãC for 19 hours.. After the reaction mixture was cooled to room temperature, ethyl acetate was added to the reaction mixture to extract it with water.. concentrated hydrochloric acid was added to the water layer to acidify it.. The water layer was washed with ethyl acetate and then concentrated, and solids deposited were collected to obtain the title compound (8.37 g).1H-NMR (DMSO-d6) delta: 8.11(2H,d,J=8.8Hz), 8.14(2H,DJ=8.8Hz), 8.35(2H,d,J=6.6Hz), 8.97(2H,d,J=6.6Hz). MS (FAB) m/z: 200(M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19524-06-2, 4-Bromopyridine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1405852; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem