Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84487-10-5, name is 2-Amino-4-bromo-3-nitropyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 84487-10-5
2-Amino-3-nitro-4-bromopyridine (1 g, 4.59 mmol)Dissolved in 20 ml of 95% ethanol, added stannous chloride(2.61 g, 13.76 mmol).The reaction solution was warmed to reflux and stirred at this temperature for 2-3 hours.Pour the reaction solution into 80 ml of 1N sodium hydroxide solution.Extracted with ethyl acetate (30 mL×3), and the extract was washed with brine.Dry over anhydrous sodium sulfate,Concentrated to a crude product.The crude product was subjected to silica gel column chromatography ( petroleum ether / ethyl acetate = 5:1)2,3-diamino-4-bromopyridine(322 mg, yield 37%)
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Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem