Adding a certain compound to certain chemical reactions, such as: 116632-24-7, 2-Amino-4,6-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-4,6-dichloropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Amino-4,6-dichloropyridine
A mixture of 2-amino-4,6-dichloropyridine (1.0 g, 6.1 mmol) and isopropylamine (5.0 mL. 61.1 mmol) was heated to 140 C in a microwave for 12h. The reaction was cooled to room temperature, concentrated and the crude residue was purified by FCC (40 g SiO2, 0 to 30% EtOAc : hexane) to afford 4-chloro-N2-isopropylpyridine-2,6-diamine (0.46 g, 40%). MS (ESI): mass calcd. for C8H12ClN3, 185.1; m/z found, 186.1 [M+H]+. 1H NMR (CDCl3): 5.80 (d, J = 1.4 Hz, 1H), 5.75 (d, J = 1.4 Hz, 1H), 4.28 – 4.18 (m, 3H), 3.77 – 3.67 (m, 1H), 1.19 (d, J = 6.4 Hz, 6H).To a solution of 4-chloro-N2-isopropylpyridine-2,6-diamine (100 mg, 0.54 mmol) in i-PrOH (1.0 mL) was added N-methylpiperazine (108 mg. 1.1 mmol) and ytterbium trifluoromethanesulfonate hydrate (378 mg. 0.59 mmol). The reaction was heated to 160 C in a microwave for 2h. The reaction was cooled to room temperature, concentrated and the crude residue was purified by FCC (12 g SiO2, 0 to 10% 2.0 M ammonia in MeOH : CH2Cl2) to afford the title compound 8a (30 mg, 22%). MS (ESI): mass calcd. for C13H23N5, 249.2; m/z found, 250.2 [M+H]+. 1H NMR (CDCl3): 5.36 (d, J = 1.8 Hz, 1H), 5.26 (d, J = 1.8 Hz, 1H), 4.07 – 3.95 (m, 3H), 3.77 – 3.65 (m, 1H), 3.28 – 3.20 (m, 4H), 2.54 – 2.45 (m, 4H), 2.32 (s, 3H), 1.19 (d, J = 6.3 Hz, 6H).
The synthetic route of 116632-24-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Meduna, Steven P.; Savall, Brad M.; Cai, Hui; Edwards, James P.; Thurmond, Robin L.; McGovern, Patricia M.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 10; (2011); p. 3113 – 3116;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem