Reference of 58584-92-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 58584-92-2 as follows.
Concentrated sulfuric acid (25 mL) and 2-amino-6-chloro-nicotinic acid (4.3 g, 25 mmol) described in Production Example 4-1-1A (or 4-1-1B) were added to methanol (50 mL) while cooling with ice followed by stirring for 5 hours at 70°C. After allowing to cool on standing, the reaction mixture was neutralized with sodium bicarbonate (90 g). The resulting solid was filtered to obtain the title compound (3.2 g, 17 mmol, 68percent) as a pale brown solid. 1H-NMR spectrum (CDCl3) delta (ppm): 3.88 (3H, s), 6.62 (1 H, d J=8.2 Hz), 8.05 (1 H, d, J=8.1 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58584-92-2, its application will become more common.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1864980; (2007); A1;,
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